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Narendra Babu, K.
- Synthesis and Gastroprotective Evaluation of New Chalcone Derivatives
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Affiliations
1 Department of Pharmacology, The Erode College of Pharmacy, Erode-638112, Tamilnadu, IN
1 Department of Pharmacology, The Erode College of Pharmacy, Erode-638112, Tamilnadu, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 5, No 6 (2013), Pagination: 325-330Abstract
The etiology of gastrodeodenal ulcers is influenced by various aggressive and defensive factors such as acid pepsin secretion, parietal cells, mucosal barrier, mucous secretion, blood flow, cellular regeneration, endogenous productive agents (PGS and epidermic growth factors), and Helicobacter pylori (H. pylori). However, it has been suggested that free radicals are closely related with peptic ulcer and gastritis. Oxygen free radicals are detrimental to the integrity of biological tissues and mediate their injury. The mechanism of damage involves lipidperoxidation, which destroys cell membranes with the release of intracellular components, such lysosomal enzymes, leading to further tissue damage. The radicals also promote mucosal damage by causing degradation of the epithelial basement membrane components, complete alteration of the cell metabolism and DNA damage. Therefore, by scavenging free radicals, the reactive oxygen metabolites might be useful by protecting the gastric mucosa from oxidative damage or by accelerating healing of gastric ulcer. Antioxidants act as scavengers inhibit lipidperoxidation and other free radicals mediated process, and therefore they protect the human body from several diseases attributed to the reactions of radicals. In this study, the gastroprotective effect of orally administrable newly synthesized chalcone derivatives on gastric lesions by pylorus ligation induced gastric ulcer in rats and In vitro free radical scavenging activity were studied.Keywords
Gastrodeodenal Ulcers, Helicobacter pylori, Oxygen Free Radicles, Antioxidants, Chalcone.References
- Calliste CA, Le Bail JC, Trouilas P, Pouget C, Habrioux G, Chulia AJ, Duroux JL. Chalcones: Structural requirements for antioxidant, Estrigenic and anti proliferative activities. Anticancer Res 2001; 21: 3949-3956.
- Blois M.S. Antioxidant determinations by the use of stable free radical. Nature 1958; 181: 1199-1200.
- Garratt DC. The quantitative analysis of Drugs. Chapman and Hall ltd, Japan; 1964: Volume 3:456-458.
- Shay H, Komarov SA, Fels SS, Meranze D, Gruenstein M, Siplet H. A Simple Method for the Uniform Production of Gastric Ulceration in the Rat Gastroenterol 1945; 5:43.
- Rajkapoor B, Anandan R, Jayakas B. Anti‐ulcer effect of Nigella saliva Linn. against gastric ulcers in rats. Current Science 2002; 82 (2):177-179.
- Laakshmayya RMB, Kuma P, Mahurkar NK, Setty SR. Pharmacological screening of ischolar_main of Operculina turpethum and its formulation. Acta Pharmaceutica Sciencia 2006.
- On the Genesis of Indian Beryls
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Authors
Affiliations
1 Centre for Earth Science Studies, Trivandrum - 695 031, IN
1 Centre for Earth Science Studies, Trivandrum - 695 031, IN
Source
Journal of Geological Society of India (Online archive from Vol 1 to Vol 78), Vol 51, No 3 (1998), Pagination: 323-330Abstract
Beryl samples collected from pegmatites of Bihar, Rajasthan, Andhra Pradesh and Kerala. Showed marked correlations between chemical constituents and physical parameters. The following are the major observations of this study: (i) Specific gravity and refractive index vary with alkali elements, (ii) unit cell dimensions vary with divalent metal ions and alkali elements, (iii) Be content correlates with refractive index, unit cell dimension c and also with Li content. Beryl samples are alkali-poor and form two distinct populations with alkali concentration of 0.594-0.863 wt% and 1.468-1.871 wt%. These two chemical types of beryls possibly tally with two generations, one of primary zones and the other of late phase cleavelandite. The data also showed that the analysed beryls from Indian pegmatites contain extremely low concentrations of rare alkalies. Correlation of Al with divalent metal ions; and Be with Li signifies that both octahedral and tetrahedral substitutions can take place in these beryls. In the structural formula the sum (Al3++Me2+), in all cases, showed close proximity to 2 justifying octahedral substitution.Keywords
Economic Geology, Mineral Chemistry, Beryl.- Assemblages of Marine Polychaete Genus Glycera (Phyllodocida: Glyceridae) Along the Kerala Coast as an Indicator of Organic Enrichment
Abstract Views :173 |
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Authors
Affiliations
1 Chemistry and Marine Biology Laboratory, Chemical Sciences Division, Centre for Earth Science Studies, Thiruvananthapuram-635 031, Kerala, IN
2 School of Applied Life Sciences, Mahatma Gandhi University Regional Centre, Pathanamthitta-689 645, Kerala, IN
1 Chemistry and Marine Biology Laboratory, Chemical Sciences Division, Centre for Earth Science Studies, Thiruvananthapuram-635 031, Kerala, IN
2 School of Applied Life Sciences, Mahatma Gandhi University Regional Centre, Pathanamthitta-689 645, Kerala, IN
Source
Nature Environment and Pollution Technology, Vol 10, No 3 (2011), Pagination: 395-398Abstract
The seasonal distribution of the polychaete genus Glycera was studied, especially in relation to the textural characteristics of sediments along the south-west Kerala coast of India. Statistical analysis pointed towards the preference of Glycera sp. in sediments rich in silt, clay, sand and organic carbon relating to their role as an indicator of organic enrichment.Keywords
Arabian Sea, Sediment Texture, Polychaete Genus Glycera, Organic Enrichment Indicator.- Formulation and Evaluation of Capecitabine Immediate Release Tablets
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Authors
Affiliations
1 Department of Pharmaceutics, Arulmigu Kalasalingam College of Pharmacy, Tamilnadu, IN
1 Department of Pharmaceutics, Arulmigu Kalasalingam College of Pharmacy, Tamilnadu, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 6, No 3 (2014), Pagination: 212-217Abstract
The present investigation was to develop immediate release (IR) tablet formulations of Capecitabine an anti-cancer drug, using Hydroxy Propyl Methyl Cellulose (HPMC E5) as binding agent. The tablets were prepared by wet granulation process and evaluated for various physico-chemical/mechanical parameters. Among the formulations the optimised formulation was identified by comparing dissolution profiles with innovator. The formulation containing 97.5mg MCC (Avicel PH 101) as filler and 20mg HPMC E5 as binder gave a bioequivalent dissolution profile as innovator over a period of 60min (100.8 %). The dissolution data of optimized formulation was also evaluated for drug release kinetics and mechanisms. The significant factor for optimised formulation and innovator was evaluated.Keywords
Immediate Release (IR) Tablets, Capecitabine (API), HPMC, MCC And Significant Factor.- Formulation and Comparative Evaluation of Aceclofenac Oral Disintegrating Tablets Using Natural Disintegrants
Abstract Views :186 |
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Authors
Affiliations
1 Department of Pharmaceutics, Krishna Teja Pharmacy College, Renigunta Road- 517520 Tirupati, Andhra Pradesh, IN
2 Department of Pharmaceutics, Krishna Teja Pharmacy College, Renigunta Road- 517520 Tirupati, Andhra Pradesh,, IN
1 Department of Pharmaceutics, Krishna Teja Pharmacy College, Renigunta Road- 517520 Tirupati, Andhra Pradesh, IN
2 Department of Pharmaceutics, Krishna Teja Pharmacy College, Renigunta Road- 517520 Tirupati, Andhra Pradesh,, IN